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目的:比较不同剂量甘露醇对脑出血患者的临床疗效。方法:选取2012年3月—2014年3月接收的脑出血患者50例为对象,根据甘露醇的用量不同将其分为观察组(25例)与对照组(25例);观察组患者接受20%甘露醇注射液125 m L治疗,对照组患者接受20%甘露醇注射液250 m L,比较两组患者治疗后的总有效率、血肿扩大率及肾功能相关指标的变化情况。结果:观察组患者治疗后的总有效率为84.00%,略高于对照组为80.00%,两组患者均按《临床神经功能缺损程度评分标准(1995年)》要求评分,组间其值经比较其差异无统计学意义(P>0.05);观察组患者治疗后肾功能各指标明显优于对照组(P<0.05),血肿扩大率为4.00%显著优于对照组为16.00%(P<0.05)。结论:不同剂量甘露醇对脑出血患者产生的临床疗效各不相同,小剂量甘露醇对脑出血患者的肾功能产生的影响较小,且能有效防止血肿的扩大。
Objective: To compare the clinical effects of different doses of mannitol on patients with intracerebral hemorrhage. Methods: Fifty patients with cerebral hemorrhage who received from March 2012 to March 2014 were selected and divided into observation group (25 cases) and control group (25 cases) according to the dosage of mannitol. Patients in observation group 20% mannitol 125 m L and control group received 20% mannitol 250 m L, the total effective rate, hematoma expansion rate and renal function-related changes after treatment were compared between the two groups. Results: The total effective rate of the observation group was 84.00% after treatment, slightly higher than that of the control group (80.00%). Both groups were scored according to the requirements of the score of clinical neurological deficit (1995) Compared with the control group, the index of renal function of the observation group was significantly better than that of the control group (P <0.05), the expansion rate of hematoma was 4.00%, which was significantly better than that of the control group (16.00%, P < 0.05). Conclusion: The clinical effects of different doses of mannitol on patients with intracerebral hemorrhage are different. Low dose mannitol has little effect on renal function in patients with intracerebral hemorrhage, and can effectively prevent the expansion of hematoma.