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据《中华结核和呼吸杂志》1995年18卷第1期报道 云南锡矿矿工肺癌实验病因学研究课题组、昆明医学院病理教研室黄润等,为探明该矿矿工肺癌高发的病因,对实验性肺癌进行了系列研究。 结果发现,甲基胆蒽,苯并芘及二乙基五硝胺均能诱发作为模型的金仓鼠肺癌。锡矿粉及其所含砷、铅、铁、铝、钛、锌、铬、锰、锫、镍、镉、钒、镀、银等15种化学成分(代号CM_1)和砷、铅、铁、铬、镍、镉、镀等7种无机化学成分(代号CM_2)均可诱发金仓鼠肺癌。CM_1及CM_2的Ames试验、细胞转化试验均为阳性;冶炼厂烟尘Ames试验及诱癌实验亦均为阳性,表明锡矿粉及其部分成分的混合尘,以及冶炼厂烟尘均有致肺癌效应。作者认为,云南锡矿矿工肺癌高发为多因素综合作用所
According to “Journal of Tuberculosis and Respiratory Diseases”, Vol.18, No.1, 1995, the study group of the lung cancer experimental etiology of Yunnan tin miners and the pathology department of Kunming Medical College, Huang Run, etc., in order to explore the causes of the high incidence of lung cancer in miners of this mine, Lung cancer has undergone a series of studies. As a result, it was found that methyl-cholesterol, benzopyrene and diethyl penta-nitramine can all induce hamster lung cancer as a model. Tin mineral powder and its 15 arsenic, lead, iron, aluminum, titanium, zinc, chromium, manganese, antimony, nickel, cadmium, vanadium, plating, silver and other 15 chemical components (code name CM_1) and arsenic, lead, iron, Seven kinds of inorganic chemical components such as chromium, nickel, cadmium, and plating (code CM_2) can induce hamster lung cancer. Ames test and cell transformation test of CM_1 and CM_2 were all positive; Ames test and carcinogenicity test of the smeltery were also positive, indicating that the mixed dust of the tin ore and some of its components, as well as smoke and dust from the smelting plant all had the effect of causing lung cancer. The author believes that the high incidence of lung cancer in Yunnan tin miners is a multi-factor comprehensive role.