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目的:探讨舍曲林对卒中后抑郁患者运动功能的恢复及生活质量的影响。方法:将126例卒中后抑郁患者随机分入对照组与观察组,62例对照组患者接受常规脑血管病治疗及康复训练。64例观察组患者在常规治疗基础上加用舍曲林口服,治疗8周。采用汉密尔顿抑郁量表(HAMD)、Fugl-Meyer运动功能评分量表(FMA)及脑卒中影响量表(SIS 310)评估患者抑郁状况、肢体运动功能及生活质量。结果:治疗后8周观察组患者HAMD评分显著低于对照组(8.35±2.21vs 14.84±4.26,P<0.05);观察组FMA评分显著高于对照组(72.56±16.94 vs 51.29±10.22,P<0.05);SIS 310各项评分及总分显著优于对照组(P<0.05)。结论:给予脑卒中后抑郁患者舍曲林治疗,可显著改善患者抑郁状况,改善肢体功能恢复和生活质量。
Objective: To investigate the effect of sertraline on recovery of motor function and quality of life in patients with post-stroke depression. Methods: 126 patients with post-stroke depression were randomly divided into control group and observation group, and 62 patients in control group received routine cerebrovascular disease treatment and rehabilitation training. Sixty-four patients in the observation group were treated with sertraline orally for 8 weeks on the basis of routine treatment. HAMD, Fugl-Meyer Motor Function Scale (FMA) and Stroke Impact Scale (SIS 310) were used to assess the depression status, motor function and quality of life of the patients. Results: The HAMD score of the observation group was significantly lower than that of the control group at 8 weeks after treatment (8.35 ± 2.21 vs 14.84 ± 4.26, P <0.05). The FMA score of the observation group was significantly higher than that of the control group (72.56 ± 16.94 vs 51.29 ± 10.22, P < 0.05). SIS 310 score and total score were significantly better than those of control group (P <0.05). Conclusion: Sertraline given to patients with post-stroke depression can significantly improve depression and improve functional recovery and quality of life.