Background Budd-Chiari syndrome (BCS) is a posthepatic portal hypertension caused by the obstruction of the lumen of the hepatic veins or the proximal inferior vena cava (IVC).This study aimed to evaluate the clinical experience of interventional therapy for Budd-Chiari syndrome.Methods IVC venography was carried out first,the obliteration or stenosis in the IVC was opened or dilated with the hard guided wire or Rups100 puncture needle and balloon,then a stent was routinely implanted for the type of obliteration or stenosis.Results The procedure was successful in 821 out of 903 cases including IVC intervention in 760 cases,and hepatic vein intervention in 61 cases.An IVC stent was used in 517 cases and hepatic vein stent in 19 cases.There were no pulmonary embolisms,but acute renal failure occurred in eight cases,hepatic coma in two cases and acute heart failure in 43 cases.Two patients died in this group and five cases were complicated with acute IVC thrombosis.Follow up of 7 to 124 months was made in 679 cases with recurrence found in 59 cases.Conclusions Interventional therapy is safe and effective with a fast recovery for most types of BCS.It is gradually becoming the first therapeutic choice.