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目的家兔口服或静脉注射(静注)左氧氟沙星后泪液与角膜组织的药动学比较。方法选取54只家兔分成口服组和静注组(n=27),分别口服或静注左氧氟沙星24 mg·kg~(-1),不同时间采集泪液或角膜组织,高效液相色谱法测定药物浓度,3p97软件计算药动学参数。结果口服给药后泪液和角膜组织中左氧氟沙星t_(max)、c_(max)和AUC_(0-t)分别为(0.58±0.20)与(1.00±0.55)h、(34.27±11.69)与(8.51±2.72)μg·g~(-1)、(157.19±32.15)与(22.90±2.63)μg·h·g~(-1);静注后分别为(0.83±0.26)与(0.83±0.26)h、(30·44±3.18)与(6.12±0.71)μg·g~(-1)、(136.72±20.12)与(26.01±5.59)μg·h·g~(-1)。左氧氟沙星口服或静注给药后泪液和角膜组织间药物浓度和药动学参数均无显著差异(P>0.05)。结论左氧氟沙星口服和静注在家兔泪液和角膜组织中药动学参数相似。
Objective To compare the pharmacokinetics of tear and corneal tissue after oral or intravenous (intravenous) levofloxacin in rabbits. Methods Fifty-four rabbits were divided into oral group and intravenous injection group (n = 27). Patients were given oral or intravenous levofloxacin 24 mg · kg -1, respectively. Tear or corneal tissue were collected at different time, Concentration, 3p97 software to calculate pharmacokinetic parameters. Results The values of t_ (max), c_ (max) and AUC_ (0-t) of levofloxacin in tear and corneal tissue after oral administration were (0.58 ± 0.20) and (1.00 ± 0.55) h, (34.27 ± 11.69) and ± 2.72) μg · g -1, (157.19 ± 32.15) and (22.90 ± 2.63) μg · h · g -1, respectively, and were (0.83 ± 0.26) and (0.83 ± 0.26) h, 30.44 ± 3.18 and 6.12 ± 0.71 μg · g -1, 136.72 ± 20.12 and 26.01 ± 5.59 μg · h · g -1, respectively. After oral or intravenous injection of levofloxacin, there were no significant differences in drug concentration and pharmacokinetic parameters between tear and corneal tissue (P> 0.05). Conclusion Levofloxacin oral and intravenous injection in rabbit tear and corneal tissue pharmacokinetic parameters are similar.