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本文报道美国缅因州3例神经管缺损(NTD)畸胎均是由因病态肥胖而做过胃空肠造口术的妇女所分娩。第一例妇女在胃分流术后两年分娩1例无脑儿。八年后诊断为抗铁性贫血,给以输血。其血清维生素B_(12)值接近正常范围下限,对肌注维生素B_(12)有反应。未测叶酸盐含量。第二例妇女在胃空肠吻合术后六年妊娠,孕16周自然流产,当时无贫血。两年后又妊娠,妊娠中期由甲胎蛋白筛选法诊断为开放性脊柱裂。孕妇经常喝烈性酒,有贫血,
This article reports that three cases of NTD in Maine, United States, were delivered by women who underwent gastro-jejunostomy due to morbid obesity. The first case of childbirth in children two years after gastric shunt in 1 child without brain. Eight years later diagnosed as anti-iron anemia, given blood transfusion. The serum vitamin B_ (12) value close to the lower limit of normal range, intramuscular injection of vitamin B_ (12) response. Not measured folate content. The second case of women in the gastrointestinal jejunum after six pregnancy, 16 weeks of spontaneous abortion, when no anemia. Two years later, another pregnancy, mid-pregnancy by the AFP screening method diagnosed as open spina bifida. Pregnant women often drink alcohol, anemia,