论文部分内容阅读
作者用自动荧光分光光度法测定了19例脑动脉瘤破裂患者的脑室,基底池和腰穿脑脊液(CSF)中NE水平。12例患者于蛛网膜下腔出血后3天内,血管痉挛发生前进行了手术。术后从基底池和侧脑室抽取CSF。有血管痉挛的患者,其基底池CSF中NE水平显著高于无痉挛者(无痉挛者为0.075±0.011ng/ml,有痉挛者为0.246±0.049ng/ml P<0.001。尽管如此,作者认为这种升高并不足以使脑动脉收缩,除非暴露于蛛网膜下腔的动脉对NE敏感性增加。为了证实这一观点,作者作了两组不同的体内试验。一组为5只家兔,注射自家血于脑池后24小时,经斜坡暴露基底动脉,在清除蛛网膜下腔围绕在动脉周围的血液后,立即可观察到血管痉挛。然后用各种人工CSF浴洗基
Autofluorescence spectrophotometry was used to determine NE levels in ventricular, basal and lumbar cerebrospinal fluid (CSF) of 19 patients with ruptured cerebral aneurysms. Twelve patients underwent surgery before vasospasm within 3 days after subarachnoid hemorrhage. CSF was extracted from basal cistern and lateral ventricle after surgery. In patients with vasospasm, NE levels were significantly higher in basal pool CSF than in those without spasticity (0.075 ± 0.011 ng / ml for spasm-free subjects and 0.246 ± 0.049 ng / ml for spastic subjects, p <0.001. Nonetheless, the authors concluded that This elevation was not enough to cause cerebral artery contractions unless the arteries exposed to the subarachnoid increased their sensitivity to NE.To validate this view, the authors made two different in vivo studies, one in five rabbits , 24 hours after injection of own blood in the brain pool, the basilar artery was exposed by the slope, and vasospasm was observed immediately after the clearance of the blood in the subarachnoid space around the artery, followed by washing with a variety of artificial CSF baths