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目的探讨昆明小鼠在免疫抑制和非免疫抑制条件下,感染相同剂量3株人源隐孢子虫分离株的排卵规律。方法饮水中加地塞米松(DEX)抑制小鼠免疫功能,人工灌胃隐孢子虫卵囊(CSO)感染小鼠,观察小鼠粪便中CSO排出规律和小鼠临床表现。结果1号和2号分离株感染小白鼠后的排隐孢子虫卵囊规律几乎一致,二者与3号分离株感染小白鼠后的排隐孢子虫卵囊规律差别较大。结论可见能够感染人的隐孢子虫的虫种具有广泛性,这些研究结果,为进一步了解隐孢子虫的人畜互传途径和隐孢子虫病的防治提供了重要的理论依据,并为人源隐孢子虫病的分子流行病学研究打下了良好基础。
Objective To investigate the ovulation of Kunming mice infected with three isolates of human Cryptosporidium isolates under immunosuppressive and non-immunosuppressive conditions. Methods Dexamethasone (DEX) in drinking water was used to inhibit the immune function in mice. The mice were challenged with Cryptosporidium oocysts (CSO) by intragastric administration, and the mice ’s excretion of CSO and their clinical manifestations were observed. Results The results showed that the rule of Cryptosporidium parvum oocysts was almost the same after inoculation of mice in No.1 and No.2 isolates. Conclusions It can be seen that the species of Cryptosporidium that can infect humans is extensive. These findings provide an important theoretical basis for further understanding of the route of transmission between humans and animals of Cryptosporidium and the prevention and treatment of Cryptosporidium. Cryptosporidium Molecular epidemiology of insect diseases lay a good foundation.