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目的:探讨氨甲蝶呤（MTX）和米非司酮联合治疗非破裂型输卵管妊娠的效果。方法:米非司酮100mg/d,共3d口服,MTX1mg/kg静注1次,第2天肌注甲酰四氢叶酸0.1mg/kg解毒1次;同样方法单用MTX的病人及单用米非司酮的病人设为对照组。结果:MTX和米非司酮联合治疗的成功率为80.3％,明显高于对照组。现察治疗期间病情变化,发现疗效与血β-HCG高低及有无心管搏动有关。结论:MTX和米非司酮联合治疗非破裂型输卵管妊娠安全有效,适用于生命体征平稳,无剧烈腹痛、无心管搏动及血β-HCG<50IU/L的非破裂型输卵管妊娠。
Objective: To investigate the effect of methotrexate (MTX) and mifepristone in the treatment of non-ruptured tubal pregnancy. Methods: Mifepristone 100mg / d, a total of 3 d oral, MTX1mg / kg intravenous injection, the first 2 days of leucovorin 0.1mg / kg detoxification 1; the same method MTX alone patients and single use Mifepristone patients as a control group. Results: The success rate of combined treatment of MTX and mifepristone was 80.3%, which was significantly higher than that of the control group. Changes were observed during treatment and found that efficacy and blood levels of β-HCG and whether the cardiac catheterization related. Conclusion: The combination of MTX and mifepristone in the treatment of non-ruptured tubal pregnancy is safe and effective. It is suitable for non-ruptured tubal pregnancy with stable vital signs, no severe abdominal pain, no cardiac tube beating and blood β-HCG <50IU / L.