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目的:探讨肿瘤坏死因子-α、白细胞介素-6和白细胞介素-2受体在甲状腺良恶性肿瘤患者外周血中表达水平的变化及与甲状腺癌分期之间的关系。方法:应用ELISA检测38例甲状腺癌和50例甲状腺腺瘤患者肿瘤坏死因子-α、白细胞介素-6和白细胞介素-2受体水平,并与50例健康志愿者对照。结果:甲状腺癌组外周血浆肿瘤坏死因子-α、白细胞介素-6和白细胞介素-2受体水平明显高于甲状腺瘤组和对照组(P<0.01),且Ⅲ,Ⅳ期甲状腺癌患者表达水平明显高于Ⅰ,Ⅱ期患者,组间比较差异有统计学意义(P<0.01)。结论:外周血肿瘤坏死因子-α、白细胞介素-6和白细胞介素-2受体表达水平与甲状腺癌的发生发展关系紧密,检测其表达水平对甲状腺肿瘤的诊断及判断预后有一定参考价值。
Objective: To investigate the changes of the expression of tumor necrosis factor-α, interleukin-6 and interleukin-2 receptor in peripheral blood of benign and malignant thyroid tumors and its relationship with the staging of thyroid cancer. Methods: Tumor necrosis factor-α, interleukin-6 and interleukin-2 receptor were detected by ELISA in 38 cases of thyroid carcinoma and 50 cases of thyroid adenoma and compared with 50 healthy volunteers. Results: The levels of tumor necrosis factor-α, interleukin-6 and interleukin-2 in thyroid cancer group were significantly higher than those in thyroid tumor group and control group (P <0.01), and thyroid cancer patients in stage Ⅲ and Ⅳ The expression level was significantly higher in patients with stage Ⅰ and Ⅱ, the difference was statistically significant (P <0.01). Conclusion: The expression levels of tumor necrosis factor-α, interleukin-6 and interleukin-2 in peripheral blood are closely related with the occurrence and development of thyroid cancer. To detect the expression level of tumor necrosis factor-α, interleukin-6 and interleukin-2 receptor has some reference value for the diagnosis and prognosis of thyroid tumors .