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目的盐酸法舒地尔治疗急性缺血性脑卒中患者对C-反应蛋白和内皮功能的影响。方法将入选患者随机分为盐酸法舒地尔治疗组和尼莫地平对照组,于治疗前、治疗后14 d分别进行内皮功能测定、C-反应蛋白的检测。结果治疗组C-反应蛋白明显下降,内皮功能明显改善,与对照组比较差异有统计学意义(P<0.05)。结论盐酸法舒地尔注射液能降低缺血性脑卒中患者C-反应蛋白的含量,同时改善患者的内皮功能。
Effect of Fasudil Hydrochloride on C-reactive Protein and Endothelial Function in Patients with Acute Ischemic Stroke. Methods The patients were randomly divided into fasudil hydrochloride group and nimodipine control group. Endothelial function and C-reactive protein were detected before treatment and 14 days after treatment respectively. Results The C-reactive protein in the treatment group decreased significantly and the endothelial function improved obviously. The difference was statistically significant compared with the control group (P <0.05). Conclusion Fasudil hydrochloride injection can reduce the content of C-reactive protein in ischemic stroke patients and improve the endothelial function.