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目的:探讨儿茶辅助治疗婴幼儿轮状病毒肠炎的疗效。方法:将78例大便轮状病毒抗原检测阳性的腹泻婴幼儿按随机数字表法分为治疗组和对照组各39例。两组常规给予退热、补液、纠正酸中毒、调节菌群等治疗。对照组给予利巴韦林10~15 mg/(kg·d)静脉滴注,每天1次;治疗组除给予利巴韦林静脉滴注外,加用儿茶50 mg/(kg·d)碾碎分2次口服,连续治疗3 d后,对两组患儿治疗总有效率、退热时间、止吐时间、止泻时间及不良反应进行比较分析。结果:治疗组总有效率92.3%,对照组总有效率56.4%,两组比较差异有统计学意义(P<0.01);治疗组患儿退热时间(3.33±1.28)d、止吐时间(1.53±0.57)d、止泻时间(2.20±0.78)d,较对照组患儿退热时间(4.08±0.97)d、止吐时间(2.33±1.11)d、止泻时间(4.87±0.94)d、明显缩短,差异有统计学意义(P<0.05)。两组均未见明显不良反应。结论:儿茶辅助治疗婴幼儿轮状病毒肠炎可有效改善临床症状,值得临床推广应用。
Objective: To investigate the efficacy of catechu as an adjuvant treatment of infantile rotavirus enteritis. Methods: 78 cases of stool rotavirus antigen positive diarrhea infants detected by random number table divided into treatment group and control group, 39 cases. Two groups routinely given fever, fluid, correct acidosis, regulation of flora and other treatment. Control group was given ribavirin 10 ~ 15 mg / (kg · d) intravenously once a day; the treatment group was given ribavirin intravenous infusion plus Catechu 50 mg / (kg · d) Crushed 2 times orally, after 3 consecutive days of treatment, the two groups of children with total effective rate of treatment, antipyretic time, antiemetic time, antidiarrheal time and adverse reactions were compared. Results: The total effective rate was 92.3% in the treatment group and 56.4% in the control group, the difference between the two groups was statistically significant (P <0.01); the treatment group had the best antipyretic time (3.33 ± 1.28) d, antiemetic time 1.53 ± 0.57) d and 2.21 ± 0.78 d, respectively. Compared with the control group, the antipyretic time (4.08 ± 0.97) d, the antiemetic time (2.33 ± 1.11) d and the diarrhea time (4.87 ± 0.94) d , Significantly shortened, the difference was statistically significant (P <0.05). No obvious adverse reactions were found in both groups. Conclusion: Cochrane assisted treatment of infantile rotavirus enteritis can effectively improve the clinical symptoms, it is worthy of clinical promotion and application.