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目的探讨高同型半胱氨酸血症和缺血性脑血管疾病间的相关性,为其防治缺血性脑血管病提供依据。方法 124例缺血性脑血管病患者按患者头颅CT与核磁共振成像检查以及脑血管病临床诊断标准分为脑梗死组62例和短暂性脑缺血发作(TIA)组62例,选择同期在本院体检的健康体检者62例为对照组。比较三组患者血浆同型半胱氨酸测定结果。结果脑梗死组、TIA组、对照组血浆同型半胱氨酸测定结果经方差分析比较得出的结论 :脑梗死组与TIA组血浆同型半胱氨酸测定结果比较,差异无统计学意义(P>0.05);脑梗死组与TIA组血浆同型半胱氨酸水平显著高于对照组,差异有统计学意义(P<0.01)。结论同型半胱氨酸水平升高是引发缺血性脑血管病的一个重要独立危险因子,临床可通过降低和控制缺血性脑出血患者的血浆同型半胱氨酸水平来降低缺血性脑血管病的发生率和复发率,提高缺血性脑血管病的康复率。
Objective To investigate the correlation between hyperhomocysteinemia and ischemic cerebrovascular disease, and to provide basis for its prevention and treatment of ischemic cerebrovascular disease. Methods 124 patients with ischemic cerebrovascular disease were divided into cerebral infarction group (n = 62) and transient ischemic attack group (n = 62) according to the patients’cranial CT and magnetic resonance imaging examination and the clinical diagnostic criteria of cerebrovascular disease. During the same period, The physical examination of our hospital 62 cases of healthy people as the control group. Plasma homocysteine levels were compared between the three groups. Results The plasma homocysteine levels in cerebral infarction group, TIA group and control group were compared by ANOVA. The results of plasma homocysteine in cerebral infarction group and TIA group showed no significant difference (P > 0.05). The levels of plasma homocysteine in cerebral infarction group and TIA group were significantly higher than those in control group (P <0.01). Conclusions Homocysteine level is an important independent risk factor for ischemic cerebrovascular disease. It can reduce ischemic brain by decreasing and controlling plasma homocysteine level in patients with ischemic cerebral hemorrhage Vascular disease incidence and recurrence rate, improve the recovery rate of ischemic cerebrovascular disease.