本文测定了慢性阻塞性肺部疾患(COPD)患者及动物组胺及溶酶体酶的变化。结果表明,COPD者痰液中组胺含量明显增高,并与病情间有一定关系;SO_2吸入所致大鼠慢性支气管炎时,肺组胺含量明显增高,哮喘患者在疾病的急性发作期,血浆中组胺含量及β-葡萄糖醛酸酶(β-g)活性均明显增高,肺气肿者血浆β-g仅有轻度增高,而血浆组胺无显明变化。讨论了组胺及溶酶体酶在COPD发病中的意义。 This article measured histamine and lysosomal enzymes in patients with chronic obstructive pulmonary disease (COPD) and animals. The results showed that the histamine in sputum of patients with COPD was significantly increased, and with a certain relationship between the condition; SO 2 inhalation induced chronic bronchitis, lung histamine significantly increased, asthma patients in the acute phase of the disease, plasma Histamine content and β-glucuronidase (β-g) activity were significantly increased in patients with emphysema plasma β-g only slightly increased plasma histamine no significant change. The significance of histamine and lysosomal enzymes in the pathogenesis of COPD was discussed.