目的　观察硝酸甘油贴膜治疗早产的临床效果 ,并初步探讨其作用机理。方法　 6 0例先兆早产患者随机分为硫酸镁加舒喘灵常规治疗组 (常规组 ,30例 )和硝酸甘油贴膜治疗组 (贴膜组 ,30例 ) ,两组孕妇治疗前、后分别抽取外周静脉血 ,采用放射免疫分析法测定血浆促肾上腺皮质激素释放激素 (CRH)水平。观察两组孕妇延迟分娩的时间。结果　 (1)贴膜组延迟分娩 4 8h ,有效率为90 % ,平均延长孕期 2 5d。常规组延迟分娩 4 8h ,有效率为 80 % ,平均延长孕期 8d。贴膜组延长先兆早产孕妇孕期效果明显优于常规组 (P <0 0 1)。 (2 )贴膜组孕妇血浆中CRH水平由治疗前的 (2 5 7±6 1)ng/L ,显著下降至治疗后的 (38± 17)ng/L。常规组孕妇血浆CRH水平由治疗前的 (2 4 8± 6 0 )ng/L ,显著降低至治疗后的 (5 6± 2 2 )ng/L ,两组比较 ,差异有极显著性 (P <0 0 1)。结论　硝酸甘油贴膜是一种安全有效的抗早产药物 ,其作用机理可能与降低血浆CRH水平有关 Objective To observe the clinical effect of nitroglycerin film in the treatment of prematurity and to explore its mechanism. Methods Sixty patients with threatened preterm birth were randomly divided into conventional treatment group (30 cases) and nitroglycerin treatment group (30 cases). The pregnant women were divided into two groups: Venous blood was collected and plasma corticotropin-releasing hormone (CRH) levels were measured by radioimmunoassay. Observation of two groups of pregnant women delayed delivery time. Results (1) Delayed childbirth 48 h, the effective rate was 90%, the average extension of pregnancy 25 days. Conventional delayed delivery 48 h, the effective rate was 80%, the average extension of pregnancy 8d. The effect of pre-delivery prolongation of preterm pregnant women in the film-dressing group was significantly better than that in the conventional group (P <0.01). (2) The plasma levels of CRH in the pregnant women of the film-dressing group decreased significantly from (257 ± 6 1) ng / L before treatment to (38 ± 17) ng / L after the treatment. The plasma levels of CRH in the pregnant women of the conventional group were significantly lower than those of the pregnant women before (2.4 ± 0.6) ng / L and (56 ± 2 2) ng / L, respectively <0 0 1). Conclusion Nitroglycerin film is a safe and effective anti-premature drug, its mechanism may be related to the reduction of plasma CRH levels