脑脊液鼻漏由未经治疗的垂体腺瘤引起者甚为罕见,作者报告一例患者间歇性脑脊液鼻漏十年,一直被诊断为慢性鼻窦炎,后因并发脑膜炎住院检查,经过一系列检查诊断为垂体腺瘤,感染经扰菌素控制后,作经蝶窦入路手术切除肿瘤,手中发现鞍底已消失,可见有一3厘米直径裂孔,鞍内肿块从中突入蝶窦,脑脊液通过肿块流出,肿块经病理检查确定为垂体腺瘤,全切除肿瘤及多次修补漏口,最后治愈.作者复习了文献,在一组109例脑脊液漏的病因分析中,由于肿瘤,主要是垂体腺瘤所致者,为数不到6%,大多数为外伤性或医源性损伤所致.另一组400例垂体腺瘤中,仅9例并发脑脊液鼻漏,此9例均曾经放疗或手术加放疗.未经治疗的垂体腺瘤引起者极为罕见.Nutkiewicz等认为,强韧的 Cerebrospinal rhinorrhea is rarely caused by untreated pituitary adenomas. The authors reported a case of intermittent cerebrospinal fluid leakage for 10 years. They have been diagnosed with chronic sinusitis and have been diagnosed with concomitant meningitis after a series of examinations. For pituitary adenomas, the infection was controlled by the sinus tract transurethral approach after surgical control of the transsphenoidal sinus approach. The saddle bottom was found to have disappeared and a 3 cm diameter hole was seen. The intrasellar mass protruded into the sphenoid sinus and the cerebrospinal fluid flowed out through the lump. The tumor was confirmed by pathological examination as pituitary adenoma, total resection of the tumor and multiple repair of leakage, and finally cured. The authors reviewed the literature, in a group of 109 cases of cerebrospinal fluid leakage etiology analysis, due to tumor, mainly due to pituitary adenoma Of the 400 cases of pituitary adenomas, only 9 cases were complicated with cerebrospinal fluid rhinorrhea. All of these 9 cases were treated with radiotherapy or surgery plus radiotherapy. Untreated pituitary adenomas are extremely rare. Nutkiewicz et al. believe that tough