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目的:通过比较非霍奇金淋巴瘤(NHL)患者与肺癌患者乙型肝炎病毒(HBV)感染率的差异,进一步探讨HBV感染与NHL之间的关系。方法:回顾性分析2000-01-2009-02在浙江省肿瘤医院住院治疗的1279例NHL患者和随机抽取同期住院的1340例肺癌患者HBV抗原抗体表达情况,并判断其差异性。结果:NHL患者HBsAg阳性率较肺癌患者差异有统计学意义(χ2=13.30,P=0.000),其HBsAg、HBeAb和HBcAb及HBsAg、HBeAg和HBcAb阳性率均明显高于肺癌患者(χ2=4.60,P=0.032;χ2=45.09,P=0.000);两组之间抗体阳性率差异均无统计学意义。同时B细胞性NHL患者的HBsAg阳性率明显高于肺癌患者(χ2=22.18,P=0.000);而T细胞性NHL患者与肺癌患者的HB-sAg阳性率差异无统计学意义,χ2=1.03,P=0.309。在NHL两亚型之间,B细胞性NHL患者的HBsAg阳性率明显高于T细胞性NHL患者(χ2=5.06,P=0.024)。结论:NHL患者HBV感染率明显高于肺癌患者,B细胞性NHL患者的感染率高于T细胞性NHL;提示HBV持续感染可能在NHL尤其在B细胞性NHL发病中起重要作用;为制定NHL的防治策略提供了参考依据。
OBJECTIVE: To further investigate the relationship between HBV infection and NHL by comparing the differences in the rate of hepatitis B virus infection among non-Hodgkin’s lymphoma (NHL) patients and lung cancer patients. Methods: The HBV antigen antibody expression in 1279 NHL patients hospitalized in Zhejiang Cancer Hospital from 2000-01-2009-02 and 1340 lung cancer patients randomly selected in the same period were analyzed retrospectively. The differences were also analyzed. Results: The positive rate of HBsAg in patients with NHL was significantly higher than that in patients with lung cancer (χ2 = 13.30, P = 0.000). The positive rates of HBsAg, HBeAb, HBcAb and HBsAg, HBeAg and HBcAb in NHL patients were significantly higher than those in patients with lung cancer (χ2 = 4.60, P = 0.032; χ2 = 45.09, P = 0.000). There was no significant difference in antibody positive rate between the two groups. The positive rate of HBsAg in patients with B-cell NHL was significantly higher than that in patients with lung cancer (χ2 = 22.18, P = 0.000). There was no significant difference in HBsAg positive rate between patients with T-cell NHL and lung cancer, P = 0.309. Among NHL subtypes, the positive rate of HBsAg in patients with B-cell NHL was significantly higher than that in patients with T-cell NHL (χ2 = 5.06, P = 0.024). Conclusions: The HBV infection rate in patients with NHL is significantly higher than that in patients with lung cancer. The infection rate of B-cell NHL is higher than that of T-cell NHL. It suggests that persistent HBV infection may play an important role in the pathogenesis of NHL, especially in B-cell NHL. The prevention and treatment strategies provide a reference.