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对变态反应性鼻炎和血管运动性鼻炎用鼻甲内注射皮质类固醇治疗已约25年,伹由于存在对视觉损害的危险,而对其安全性提出疑问。本文作者们曾使用丙酮氟羟泼尼松龙(10mg/ml)注射17年以上,超过6万次没有严重的副作用,仅2例发生了较严重的过敏反应,有巨大的荨麻疹,其中一例合并有支气管哮喘,用抗组织胺治疗几天恢复。一例病人有轻度的暂时性视力障碍,但眼科检查未发现病理改变,一些病人有暂时的血管扩张反应。作者认为用此法治疗过敏性和血管运动性鼻炎很有价值,对持续性过敏平均可缓解达2—3个月,对季节性过敏常可不需作进一步治疗到第二年,组织学上可看到注射后组织水肿减轻,粘膜下结缔组织相对致密。
Treatment of allergic rhinitis and vasomotor rhinitis with intranasal injection of corticosteroids has been around for about 25 years, raising questions about its safety due to the risk of visual impairment. The authors of this study used acetonefluoprofen prednisolone (10 mg / ml) for more than 17 years, with more than 60,000 injections without serious side effects and only 2 with more severe anaphylactic reactions and massive urticaria With bronchial asthma, with antihistamine treatment a few days recovery. One patient had mild temporary visual impairment, but no pathological changes were detected in the ophthalmic examination and some patients had transient vasodilator responses. The authors believe that the use of this method is valuable for the treatment of allergic and vasomotor rhinitis, the average sustainable allergy can be relieved up to 2-3 months, often without further treatment of seasonal allergies to the second year, histologically See tissue edema relief after injection, submucosal connective tissue is relatively dense.