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目的:分析7株侵袭性非伤寒沙门菌（iNTS）的血清型和耐药性。方法:针对收集的7株iNTS菌株，开展血清学鉴定、药物敏感性实验以及全基因组测序，并对血清型、MLST型和耐药基因进行鉴定、注释和分析。结果:7株iNTS菌株中，包含1株鼠伤寒血清型和2株Ⅰ 4，［5］，12：i：- （ST34型）、2株肠炎血清型、1株科瓦利斯血清型和1株未知血清型Ⅰ 4，［5］，12：d：-（ST279型），其中6株为单相菌，沙门菌二相鞭毛基因缺失或假基因化可能有助于增强沙门菌侵袭性。未发现替加环素、氨曲南、阿米卡星及头孢类、碳青霉烯类抗生素耐药株，存在1株八重耐药鼠伤寒沙门菌。耐药基因与耐药表型基本相符。结论:本研究中的iNTS菌株存在八重耐药株，整体耐药水平尚低但不可忽视。“,”Objective:To investigate the serotypes and antimicrobial resistance of seven invasive non-typhoidal n Salmonella (iNTS) isolates.n Methods:For 7 iNTS strains collected, serotype identification, antimicrobial susceptibility testing and whole genome sequencing were performed. We identified, annotated and analyzed the serotypes, MLST types, and antimicrobial resistance genes.Results:Among the 7 tested iNTS isolates, we found one n Salmonella Typhimurium strain and two n Salmonella Ⅰ 4, [5], 12: i:- strains whose MLST types were ST34, two n Salmonella Enteritidis strains, one n Salmonella Corvallis strain and one strain of unknown serotype with the antigenic formulae of Ⅰ 4, [5], 12: d:- (ST279 type). Six of seven strains were monophasic and the deletion or pseudogenization of n Salmonella Flagellum gene might contribute to the enhancement of n Salmonella invasiveness. None was found to be resistant to tigarcycline, aztreonam, amikacin, cephalosporins and carbapenem and one n Salmonella Typhimurium strain was found to be co-resistant to eight classes of antimicrobials at the same time. Resistance genes were generally in accord with relative resistant phenotypes.n Conclusion:The iNTS strains could show high level multi-drug resistance, indicating that close attention should be paid to the resistance of iNTS though the overall resistance might be relatively not high.