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目的了解兰州地区阴道加德纳菌(GV)的生物学分型、药敏和感染途径。方法根据Briselden方法对GV进行生物学分型和传播途径研究,采用微量稀释法进行药敏试验。结果细菌性阴道炎组(BV组)GV检出率51.8%,对照组(NBV组)GV检出率10.0%,差异有统计学意义(P<0.01)。共检出6种生物型,两组生物型分布有显著性差异(P<0.01)。对GV敏感的药物为:克林霉素、罗红霉素、四环素和甲硝唑。配偶间与自身不同部位检出同型菌株的几率差异无统计学意义。结论GV的不同生物型与BV发病有关,GV可通过多种途径传播,对常用药物敏感性不高。
Objective To understand the genotyping, drug sensitivity and infection of Gardnerella vaginalis in Lanzhou. Methods According to the method of Briselden, the genotyping and transmission of GV were studied, and the drug susceptibility test was carried out by using microdilution method. Results The detection rate of GV in bacterial vaginosis group (BV group) was 51.8%, while that in the control group (NBV group) was 10.0%. The difference was statistically significant (P <0.01). A total of 6 kinds of biotypes were detected, and there was a significant difference in the distribution of biotypes between the two groups (P <0.01). GV-sensitive drugs are: clindamycin, roxithromycin, tetracycline and metronidazole. There was no significant difference in the probability of detecting the same type of strains between spouses and different parts of themselves. Conclusion Different biological forms of GV are related to the pathogenesis of BV. GV can be transmitted through many ways and its sensitivity to commonly used drugs is not high.