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目的:探讨粘附分子CD44v6和基质金属蛋白酶MMP-9在宫颈癌中的表达及其与宫颈癌浸润转移的关系。方法:采用免疫组织化学S-P法检测CD44v6、MMP-9在10例正常宫颈组织(NCE)、18例宫颈上皮内瘤变(CIN)和37例宫颈浸润癌(ICC)中的表达情况,分析其表达与宫颈癌临床病理特征之间的关系以及CD44v6、MMP-9二者的相关性。结果:CD44v6与MMP-9的表达在ICC中最高,CIN中次之,NCE中最低;CD44v6、MMP-9的表达在淋巴结转移组明显高于无淋巴结转移组(P<0.O5),间质浸润深组明显高于间质浸润浅组(P<0.O5);CD44v6与MMP-9两者在宫颈癌中的表达呈正相关,其共同高表达者发生间质浸润深层和淋巴结转移的几率明显高于仅其中之一阳性表达或皆为阴性表达者。结论:CD44v6、MMP-9阳性表达率随正常宫颈组织-宫颈上皮内瘤变-宫颈癌的转化而增加;CD44v6、MMP-9的过表达可能促进宫颈癌浸润和淋巴结转移,且二者在宫颈癌浸润转移过程中相互关联、协同作用。
Objective: To investigate the expression of adhesion molecule CD44v6 and MMP-9 in cervical cancer and its relationship with invasion and metastasis of cervical cancer. Methods: The expressions of CD44v6 and MMP-9 in 10 cases of normal cervical tissue (NCE), 18 cases of cervical intraepithelial neoplasia (CIN) and 37 cases of invasive cervical carcinoma (ICC) were detected by immunohistochemical SP method. Expression and clinicopathological features of cervical cancer and the relationship between CD44v6 and MMP-9. Results: The expression of CD44v6 and MMP-9 were the highest in ICC, the lowest in CIN and the lowest in NCE. The expressions of CD44v6 and MMP-9 were significantly higher in lymph node metastasis than those without lymph node metastasis (P <0.05) (P <0.05). The expression of CD44v6 and MMP-9 in cervical cancer was positively correlated with that of the deep infiltration of the interstitial infiltration group The odds of being significantly higher than only one of them were positive or negative. Conclusion: The positive rates of CD44v6 and MMP-9 increase with the transformation of normal cervical tissue-cervical intraepithelial neoplasia-cervical cancer. Overexpression of CD44v6 and MMP-9 may promote the infiltration of cervical cancer and lymph node metastasis, The process of invasion and metastasis of cancer is interrelated and synergistic.