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目的：系统评价噻奈普汀与帕罗西汀治疗抑郁症的疗效和安全性。方法计算机检索中国期刊全文数据库、维普全文数据库、万方数据库、PubMed、Medline、EmBase中关于噻奈普汀与帕罗西汀治疗抑郁症的随机对照临床试验（ RCT），用Cochrane系统评价的方法进行评价，用RevMan5.0统计软件进行Meta分析。结果共纳入8项研究，共936例患者。 Meta分析结果显示，噻奈普汀组患者显效率、汉密尔顿抑郁量表（ HAMD）评分与帕罗西汀组比较差异无统计学意义（ P＞0.05）；不良反应发生率方面，2组差异有统计学意义（ P＜0.01）。结论噻奈普汀与帕罗西汀治疗抑郁症疗效相当，不良反应少。“,”Objective To evaluate the efficacy and safety of tianeptine and paroxetine in the treatment of depression.Methods Retrieved from CNKI, VIP, Wanfang database, PubMed, Medline and EmBase, ran-domized controlled trial ( RCTs) about tianeptine or paroxetine in treat-ment of depression were collected and evaluated by Cochrane systematic review.Meta -analysis was carried out by Rev Man 5.0 software.Results Eight studies were included , involving 936 patients.Meta -analysis showed that there was no statistically significant difference on the rates of marked improvement and Hamilton depression scale( HAMD) be-tween tianeptine and paroxetine ( P>0.05 ).The incidence of adverse drug reactions in both groups had significant difference ( P <0.01 ).Conclusion Tianeptine is as effective as and safer than paroxetine in the treatment of depression.