最近皮肤用硝酸盐制剂已引用于治疗心绞痛。据说经皮给药可达到缓释,长效和直接吸收进入血循环。而硝酸酯口服给药时需经肝脏的首过代谢,以致进入体循环的摄入量减少。三硝酸甘油皮肤给药抗心绞痛作用时间长达3～8小时,异山梨醇二硝酸酯霜剂的抗心绞痛作用时间长达7小时。三硝酸甘油和异山梨醇二硝酸酯皮肤给药已用双盲对照实验研究进行评价和比较。十名心绞痛患者接受试验。患者于皮肤应用三 Recent skin nitrate preparations have been cited for the treatment of angina. It is said that transdermal delivery can achieve sustained release, long-lasting and direct absorption into the bloodstream. The oral administration of nitrates required by the first pass of the liver metabolism, resulting in reduced intake into the systemic circulation. The anti-anginal effect of glycerol trinitrate skin administration for up to 3 to 8 hours, anti-anginal effect of isosorbide dinitrate cream for up to 7 hours. Skin administration of trinitrate and isosorbide dinitrate has been evaluated and compared using a double-blind, controlled experimental study. Ten patients with angina were tested. Patients apply three on the skin