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本文用对人胎盘型谷胱甘肽S-转移酶(GST-π)抗体的ABC法检查了38例胃癌和28例胃癌前期病变及22例正常胃粘膜。观察结果表明,GST-π阳性物质为棕色,分布于细胞浆内,根据其在细胞内分布的特点可分为胞质型、周边型、分泌型和印戒型。胃腺癌组织中GST-π的阳性率可达95％以上,胃粘膜的不典型增生和肠上皮化生组织中阳性率分别达100％和85％,且活性高,但粘液腺癌、印戒细胞癌和未分化癌组织中GST-π阳性率低,而且活性也低。作者认为GST-π可作为人类胃癌和胃癌前期病变的新的标志酶。
In this study, 38 cases of gastric cancer and 28 cases of precancerous lesions and 22 cases of normal gastric mucosa were examined by ABC method of human placental glutathione S-transferase (GST-π) antibody. The observation results showed that the GST-π positive substance was brown and distributed in the cytoplasm. According to the characteristics of its distribution within the cell, the GST-π positive substance can be divided into cytoplasmic, peripheral, secretory and Indian ring type. The positive rate of GST-π in gastric adenocarcinoma tissue was more than 95%. The positive rates of gastric dysplasia and intestinal metaplasia were 100% and 85%, respectively, and the activity was high, but mucinous adenocarcinoma and signet ring The positive rate of GST-π in cell and undifferentiated cancer tissues is low, and the activity is also low. The authors believe that GST-π can be used as a new marker enzyme for human gastric cancer and precancerous lesions.