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目的:研究四逆散冻干粉改善果蝇睡眠作用的量-效与时-效关系。方法:选取野生型Canton S品系黑腹果蝇为试验对象,利用自动红外果蝇活动监测系统,以果蝇24 h总睡眠时间为观察指标,分别进行四逆散冻干粉改善睡眠作用的量-效与时-效关系的研究。结果:雌雄果蝇的24 h总睡眠时间随着给药剂量的增加而增加,具有一定的剂量依赖关系,雌果蝇的最大有效剂量是4%,而雄果蝇的最大有效剂量为2%,雌果蝇连续给药4 d果蝇24 h总睡眠时间最长,而雄果蝇连续给药7 d,其24 h总睡眠时间最长。结论:四逆散冻干粉能促进果蝇的睡眠,但对雌、雄果蝇睡眠的影响程度不同。雌果蝇给药高浓度短时间效果较好,雄果蝇给药低浓度长时间效果好。
Objective: To study the quantity-effect and time-effect relationship of freeze-dried powder of Sini powder to improve the sleep function of Drosophila melanogaster. Methods: Drosophila melanogaster, a wild type Canton S strain, was selected as experimental object. Using the automatic monitoring system of Drosophila melanogaster and the total sleep time of flies for 24 h, the amount of sleep improvement Study on the Relationship between Efficiency and Time - Efficiency. Results: The 24 h total sleep time of the male and female flies increased with the increase of the dosage, with a dose-dependent manner. The maximum effective dose of the female flies was 4%, while the maximum effective dose of the male flies was 2% , The female fruit flies administered 4 d continuous drosophila for 24 h had the longest total sleep time, while the male fruit flies dosed continuously for 7 d, the longest 24 h total sleep time. Conclusion: Sini powder freeze-dried powder can promote the sleep of fruit flies, but have different effects on the sleep of female and male flies. Drosophila administration of high concentrations of short-term effect is better, male fruit flies administered low concentration for a long time effective.