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目的 探讨幽门螺杆菌 (Helicobacterpylori,Hp)菌型差异和机体免疫反应在Hp致病中的作用及其相互关系。方法 采用间接ELISA法检测了 175例患者血清抗HpCagA IgG和抗HpIgE。结果 ①Hp感染者抗HpCagA IgG的阳性率 (80 % )明显高于抗HpIgE(5 8 2 9% ,P <0 0 1)。②血清抗HpCagA IgG在慢性活动性胃炎 (ACG)和十二指肠球部溃疡 (DU)患者显著高于胃溃疡 (GU)、胃癌(GCa)、慢性非活动性胃炎 (NACG)和对照组 (P <0 0 1) ,而后 4组之间差异无显著性。③血清抗HpIgE在ACG显著高于DU、GU、GCa、NACG和对照组 (P <0 0 1) ,并且在中重度胃炎显著高于轻度胃炎(P <0 0 0 1)。④血清抗HpCagA IgG和抗HpIgE无明显相关性 (r=0 2 45 9,P >0 0 5 )。结论 CagA和血清抗HpIgE参与了Hp的致病过程 ,但是两者之间无明显相关性 ,并且它们在疾病中的含量也有一定差异 ,这说明二者在Hp的致病过程中是相互独立的因素 ,Hp感染引起疾病是多因素的综合作用。
Objective To investigate the role of Helicobacter pylori (Hp) in the pathogenesis of H.pylori and its relationship with the immune response in Hp pathogenesis. Methods Serum anti-HpCagA IgG and anti-HpIgE were detected in 175 patients by indirect ELISA. Results ① The positive rate of anti-HpCagA IgG (80%) in Hp infected patients was significantly higher than that of anti-HpIgE (58.29%, P <0.01). ② Serum anti-HpCagA IgG was significantly higher in patients with chronic active gastritis (ACG) and duodenal ulcer (DU) than those with gastric ulcer (GU), gastric cancer (GCa), chronic non-active gastritis (P <0.01), but there was no significant difference between the last 4 groups. ③ Serum anti-HpIgE was significantly higher in ACG than in DU, GU, GCa, NACG and control group (P <0.01), and was significantly higher in moderate to severe gastritis than mild gastritis (P <0.01). ④ Serum anti-HpCagA IgG and anti-HpIgE no significant correlation (r = 0 2 459, P> 0 0 5). Conclusions CagA and serum anti-HpIgE are involved in the pathogenesis of Hp, but there is no significant correlation between them and their content in the disease, indicating that they are independent of each other in the pathogenesis of Hp Factors, Hp infection caused by the disease is a multi-factor combination.