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目的 :探讨胃癌mn2 3 H1基因表达与淋巴结转移倾向的相关性。方法 :采用地高辛标记cD NAnm2 3 H1探针 ,原位杂交检测 2 1例胃癌及癌旁组织 ;应用单克隆抗体 (NM30 1)SP法检测 131例胃癌及 60例非胃癌胃粘膜nm2 3/NDPK表达。结果 :原位杂交阳性率 57.1% ( 12 /2 1) ;免疫组化阳性率为87.8% ( 115/131) ,其中非转移组阳性率为 97.1% ( 34 /35) ,转移组阳性率 84 .4 % ( 81/96) ,P <0 .0 5。结论 :胃癌nm2 3 H1基因表达与淋巴结转移倾向呈负相关 ,与PCNA分级呈正相关
Objective: To investigate the correlation between the expression of mn2 3 H1 gene in gastric cancer and the tendency of lymph node metastasis. METHODS: Digoxigenin-labeled cDNAnm2 3 H1 probe was used to detect 21 cases of gastric cancer and paracancerous tissues by in situ hybridization. Monoclonal antibody (NM30 1) SP method was used to detect 131 cases of gastric cancer and 60 cases of non gastric cancer gastric mucosa nm2 3 /NDPK expression. Results: The positive rate of in situ hybridization was 57.1% (12/21). The positive rate of immunohistochemistry was 87.8% (115/131). The positive rate of non-metastatic group was 97.1% (34/35). The positive rate of metastatic group was 84. .4% (81/96), P <0. Conclusion: The expression of nm23H1 gene in gastric cancer is negatively correlated with lymph node metastasis and positively correlated with PCNA grade.