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采用ＥＬＩＳＡ法对４２例Ｇｒａｖｅｓ病病儿细胞因子失衡及其与发病的关系进行研究。结果：（１）与正常组相比，初诊组ＩＦＮ－γ水平、ＩＦＮ－γ／ＩＬ－４比值明显升高，ＩＬ－４水平明显降低（Ｐ＜０．００１或０．００２）；ＩＦＮ－γ抗体阳性组与阴性组相比；ＩＦＮ－γ水平、ＩＦＮ－γ／ＩＬ－４比值明显降低（Ｐ＜０．０５），而ＩＬ－４水明显升高（Ｐ＜０．００１）；且ＩＦＮ－γ／ＩＬ一４比值与血清Ｔ３和Ｔ４水平呈显著正相关（ｒ＝０．５４、０．５６和０．５５、０．６３，Ｐ＜０．０５）；（２）复诊组中，治疗效果好组ＩＦＮ一γ水平、ＩＦＮ－γ／ＩＬ－４比值明显降低（Ｐ＜０，０５），ＩＬ－４水平无明显变化（Ｐ＜０．０５）；而治疗效果差组细胞因子水平无显著变化（Ｐ＞０．０５）。提示：Ｇｒａｖｅｓ病体内存在以Ｔｂ１类占优势的细胞因子水平的失衡；抗体阳性病儿其细胞因子类型向Ｔｈ２转化；异常的细胞因子可导致甲状腺功能受损；细胞因子的监测对于Ｇｒａｖｅｓ病的病情估价、协助诊断及判断预后有一定的指导意义。
The relationship between cytokines imbalance and pathogenesis in 42 Graves’ disease children was studied by ELISA. The levels of IFN-γ / IL-4 and the levels of IL-4 in the newly diagnosed group were significantly higher than those in the normal group (P <0.001 or 0.002) (P <0.05), while the level of IL-4 was significantly increased (P <0.001); and the level of IFN-γ / IL-4 was significantly lower in the positive group than in the negative group IFN-γ / IL-4 ratio was positively correlated with serum T3 and T4 levels (r = 0.54,0.56 and 0.55,0.63, P <0.05); (2) (P <0.05). However, the treatment effect was poor in the group of IFN-γ, the ratio of IFN-γ / IL-4 was significantly decreased No significant change in level (P> 0.05). Tip: there is an imbalance of Tb1 predominant cytokines in Graves’ disease; cytokine-type conversion to Th2 in antibody-positive children; abnormal cytokines leading to impaired thyroid function; monitoring of cytokines in Graves disease Valuation to help diagnose and determine the prognosis of a certain degree of guiding significance.