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目的:探讨对比剂增强MRI评价类风湿(RA)患者用英夫利昔单抗治疗前和治疗后手部血管翳的价值。方法:本研究包括用氨甲喋呤治疗无效的13个类风湿患者(男2人,女11人, 年龄25-71岁,平均51．8岁)。制定剂量前分别行临床、血清学和MRI检查。分别于治疗后6周(n=1)、14周(n=1)、22周 (n=7)或30周(n=4)再行上述检查。MRI扫描使用0．3 T系统(HITACHI MRP 7000)。人工手动静脉注药后4 min行手部 SE T1WI扫描。比较治疗前和治疗后的MR影像(好转,加剧和没有变化),测量注射对比剂前后血管翳和邻近骨质的信号强度来评价治疗效果。相对强化值等于血管翳信号强度与骨
OBJECTIVE: To investigate the value of contrast-enhanced MRI in the evaluation of rheumatoid arthritis (RA) patients before and after treatment with infliximab. METHODS: This study included 13 rheumatoid patients (2 males and 11 females, aged 25-71 years, mean 51.8 years) who were ineffective with methotrexate. Before the development of dose, respectively, clinical, serological and MRI examination. The above examination was repeated 6 weeks (n = 1), 14 weeks (n = 1), 22 weeks (n = 7) or 30 weeks (n = 4) after the treatment. The MRI scan uses a 0.3 T system (HITACHI MRP 7000). Manual SE T1WI scan was performed 4 min after manual intravenous injection. Before and after treatment of MR images (improvement, exacerbation and no change), measured before and after injection of contrast agent and adjacent bone calcification signal intensity to evaluate the therapeutic effect. The relative enhancement value is equal to the angiogenic signal strength and bone