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目的通过流行病学调查,分析非酒精性脂肪性肝病(NAFLD)的相关危险因素,以探讨NAFLD与代谢综合征(MS)的相关性。方法 873人依据体检情况分为NAFLD组和非NAFLD组及MS组和非MS组,分析体重指数(BMI)、血压、血脂、血糖(FBG)等因素与NAFLD的相关性。结果 (1)NAFLD患病率41.123%,男性患病率高于女性(χ2=21.804,P<0.001)。MS患病率15.693%,MS组NAFLD患病率高于非MS组(χ2=99.171,P<0.001)。(2)NAFLD组BMI、FBG、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、谷丙转氨酶(ALT)、尿酸(UA)值均高于非NAFLD组(P<0.001),谷草转氨酶(AST)值高于非NAFLD组(t=3.242,P=0.001),HDL-C值低于非NAFLD组(t=3.510,P<0.001);超重和(或)肥胖、高血糖、高血压、高TG、低HDL-C、高尿酸血症、MS阳性率均高于非NAFLD组(P<0.001),肝功能异常阳性率高于非NAFLD组(t=10.119,P=0.002)。(3)NAFLD患病率随着MS诊断标准中诊断项目的增多呈上升趋势(χ2=239.918,P<0.001)。结论 MS与NAFLD密切相关,并相互影响。
Objective To investigate the correlation between NAFLD and metabolic syndrome (MS) by epidemiological investigation and to analyze the related risk factors of non-alcoholic fatty liver disease (NAFLD). Methods According to the physical examination, 873 patients were divided into NAFLD group and non-NAFLD group and MS group and non-MS group. The correlation between body mass index (BMI), blood pressure, blood lipid and blood glucose (FBG) and NAFLD was analyzed. Results (1) The prevalence of NAFLD was 41.123%. The prevalence rate of male was higher than that of female (χ2 = 21.804, P <0.001). The prevalence of MS was 15.693%. The prevalence of NAFLD in MS group was higher than that in non-MS group (χ2 = 99.171, P <0.001). (2) BMI, FBG, SBP, DBP, TG, TC, LDL-C, ALT, UA was higher in non-NAFLD group than in non-NAFLD group (t = 3.242, P = 0.001), HDL-C was lower than non-NAFLD group (t = 3.510, P <0.001). The positive rates of overweight and / or obesity, hyperglycemia, hypertension, high TG, low HDL-C, hyperuricemia and MS were higher than those in non-NAFLD group (P <0.001) The abnormal positive rate was higher than non-NAFLD group (t = 10.119, P = 0.002). (3) The prevalence of NAFLD increased with the increase of diagnosis items in MS diagnostic criteria (χ2 = 239.918, P <0.001). Conclusion MS and NAFLD are closely related and influence each other.