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目的观察改善微循环障碍对高血压病病人胰岛素抵抗的影响。方法将符合纳入标准的高血压病病人65例随机分为治疗组(35例)和对照组(30例),其中治疗组予常规降压药加用丹参酮ⅡA磺酸钠注射液静脉输注治疗,对照组予卡托普利等常规西药治疗,疗程均为4周。观察并比较各组治疗前后血压、血糖、血清胰岛素和胰岛素抵抗指数、甲襞微循环。结果治疗组降压总有效率为94.69%,明显优于对照组的86.67%(P<0.05);治疗组治疗后可降低空腹血糖和胰岛素,升高胰岛素抵抗指数,改善微循环障碍(P<0.05)。结论微循环障碍的改善对治疗高血压病胰岛素抵抗有较好的疗效。
Objective To observe the effect of improving microcirculation on insulin resistance in patients with essential hypertension. Methods A total of 65 patients with essential hypertension who were included in the standard were randomly divided into treatment group (n = 35) and control group (n = 30). Patients in the treatment group were given conventional antihypertensive drugs plus intravenous infusion of tanshinone Ⅱ A sodium sulfonate , The control group to captopril and other conventional western medicine, treatment are 4 weeks. The blood pressure, blood glucose, serum insulin and insulin resistance index and nailfold microcirculation were observed and compared before and after treatment. Results The total effective rate of antihypertensive treatment in treatment group was 94.69%, which was significantly better than that in control group (86.67%, P <0.05). After treatment, the treatment group decreased fasting blood glucose and insulin, increased insulin resistance index and improved microcirculation (P < 0.05). Conclusion The improvement of microcirculation has a good effect on the treatment of hypertension with insulin resistance.