论文部分内容阅读
近年研究发现,血清过氧化脂(LPO)水平升高与机体老化及动脉粥样硬化性疾病有密切关系。为探讨糖尿病血管并发症与LPO关系,作者对91例正常人及137例糖尿病人的血清LPO水平等参数作了测定并分析了LPO在糖尿病血管病发病机理中的可能作用。作者发现正常人LPO水平较为恒定,但有随年龄增加而升高的趋势。糖尿病人的LPO水平明显高于同年龄组正常人(5.3±0.1,3.9±0.1nmol/ml,P<0.001),但有血管并发症糖尿病组又明显高于无并发症组(5.9±0.2,4.3±0.1nmol/mL,P<0.001),且与一组住院冠心病人的LPO水平相近。
In recent years, studies have found that elevated serum lipid peroxide (LPO) and the body aging and atherosclerotic diseases are closely related. To explore the relationship between diabetic vascular complications and LPO, the authors measured serum LPO levels and other parameters in 91 normal subjects and 137 diabetic patients and analyzed the possible role of LPO in the pathogenesis of diabetic vascular disease. The authors found that normal LPO levels are relatively constant but increase with age. The level of LPO in diabetics was significantly higher than that in normal subjects (5.3 ± 0.1,3.9 ± 0.1nmol / ml, P <0.001), but the diabetic group with vascular complications was significantly higher than that without complications (5.9 ± 0.2, 4.3 ± 0.1 nmol / mL, P <0.001), similar to LPO levels in a group of hospitalized patients with coronary heart disease.