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目的研究分析脑梗死患者Hcy、UA与头颈部血管动脉粥样硬化及狭窄的相关性。方法选择濮阳市油田总医院120例脑梗死患者作为研究对象,根据患者是否存在动脉粥样硬化分成对照组(不存在动脉粥样硬化)和观察组(存在动脉粥样硬化)各60例。比较两组患者的UA和Hcy水平,观察不同血管狭窄程度患者的UA和Hcy水平,分析动脉粥样硬化严重程度与UA和Hcy水平之间的关系。结果观察组患者的UA和Hcy水平高于对照组患者的UA和Hcy,差异具有统计学意义(P<0.05)。随着血管狭窄程度的提升,UA和Hcy水平会随之不断提高,差异具有统计学意义(P<0.05)。UA和Hcy均异常升高的脑梗死患者发生重度动脉粥样硬化的比例明显高于UA或Hcy单独升高的脑梗死患者,差异具有统计学意义(P<0.05)。结论 Hcy、UA与脑梗死患者发生动脉粥样硬化及狭窄有着密切的相关性,Hcy、UA水平越高,发生动脉粥样硬化及狭窄的风险性更高,且动脉粥样硬化及狭窄的严重程度更高。
Objective To study the correlation between Hcy, UA and vascular atherosclerosis and stenosis in patients with cerebral infarction. Methods A total of 120 patients with cerebral infarction in Puyang Oilfield General Hospital were selected as study subjects and divided into control group (without atherosclerosis) and observation group (with atherosclerosis) according to the presence or absence of atherosclerosis in 60 patients. The levels of UA and Hcy in both groups were compared. The levels of UA and Hcy in patients with different degree of vascular stenosis were observed. The relationship between the severity of atherosclerosis and the levels of UA and Hcy was analyzed. Results The UA and Hcy levels in observation group were higher than those in control group (P <0.05). As the degree of vascular stenosis increased, UA and Hcy levels will continue to increase, the difference was statistically significant (P <0.05). The proportion of patients with severe atherosclerosis in patients with abnormally elevated UA and Hcy were significantly higher than those with elevated UA or Hcy alone (P <0.05). Conclusions Hcy and UA are closely related to the occurrence of atherosclerosis and stenosis in patients with cerebral infarction. The higher the Hcy and UA levels, the higher the risk of developing atherosclerosis and stenosis, and the atherosclerosis and stenosis are serious To a higher degree.