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由于碘苷(IDU)的极性作用,穿过角膜脂样上皮层的渗透性差,故广泛用于单纯疱疹性角膜炎的局部治疗,而IDU 的前体药物有可能用来治疗眼深部感染。本文对IDU 及其前体药物进行了一系列实验研究。
Because of the polar effects of iodine (IDU), the permeability across the cornea-like epithelium is poor and is therefore widely used for topical treatment of herpes simplex keratitis, while IDU’s prodrugs are potentially useful for the treatment of deep eye infections. This article conducted a series of experimental studies on IDU and its prodrugs.