目的　探讨尿激酶治疗不稳定型心绞痛的疗效及机制。方法　经过常规方法治疗无效的不稳定型心绞痛 ,在肝素、肠溶阿斯匹林基础上 ,加尿激酶 5 0万单位 /日 ,连续 3天。结果　 45例的治疗总有效率是 91.1% ,凝血酶原时间延长及纤维蛋白原降低 (P <0 .0 1)。结论　小剂量连续尿激酶联合肝素治疗不稳定型心绞痛有效 ,且高凝、低纤溶状态得到改善 Objective To investigate the efficacy and mechanism of urokinase in the treatment of unstable angina pectoris. Methods After conventional treatment of unstable angina pectoris, on the basis of heparin and enteric-coated aspirin, add 500K units of urokinase per day for 3 consecutive days. Results The total effective rate of 45 cases was 91.1%, prothrombin time and fibrinogen decreased (P <0.01). Conclusions Low-dose continuous urokinase combined with heparin is effective in treating unstable angina pectoris and its hypercoagulability and fibrinolytic status are improved