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目的对国内某焦化厂筛焦车间工人进行多环芳烃接触评价,并探讨可能的皮肤吸收途径。方法收集19例作业工人班末尿,采用高效液相色谱法测定尿中1-羟基芘含量,对其中2例样本进行个体采样和空气中多环芳烃接触评价,并根据尿中1-羟基芘浓度和空气中苯并[a]芘时间加权平均浓度的关系曲线估计尿中1-羟基芘的呼吸道吸收比例和皮肤吸收比例。结果筛焦车间筛焦工尿中1-羟基芘浓度均数为4.42μmol/mol Cr,皮带工为3.32μmol/mol Cr。筛焦车间作业工人尿中1-羟基芘的呼吸道摄人比例仅为16%左右,而经皮肤吸收则高达84%。结论焦化厂筛焦作业工人存在严重的多环芳烃接触,经皮吸收是最主要的接触途径。
Objective To evaluate PAH exposure of workers in a coking plant in a coking plant in China and to explore possible ways of skin absorption. Methods A total of 19 workers were enrolled in this study. Urinary 1-hydroxypyrene was detected by high performance liquid chromatography (HPLC). Individual samples of 2 samples were collected and airborne polycyclic aromatic hydrocarbons (PAHs) were evaluated. According to urinary 1-hydroxypyrene Concentration and the concentration of benzo [a] pyrene in air time weighted average concentration curve of urinary 1-hydroxy-pyrene respiratory absorption ratio and skin absorption ratio. Results The average concentration of 1-hydroxypyrene in the screening coke workshop was 4.42μmol / mol Cr and the belt worker was 3.32μmol / mol Cr. Screening coke workshop workers urinary 1-hydroxy-pyrene respiratory intake only about 16%, while transdermal absorption was as high as 84%. Conclusion There is a serious PAH exposure in the coke plant with scorching workers. Percutaneous absorption is the most important route of exposure.