1985年 Solerte 等曾报道糖尿病患者经己酮可可碱治疗4个月后,蛋白尿和纤维蛋白原分别降低46％和18％,推测主要是纤维蛋白原减少,加上血浆粘度的降低导致蛋白尿的减少。本文作者让4名血压正常的糖尿合并蛋白尿病人服用己酮可可碱400mg×3/d,历时4个月。入组病人全部经常规检查确证有蛋白尿。除加用己酮可可碱外,从治疗前2个月到疗程4个月结束,病人的用药情况与以前相同。己酮可可碱治疗开始前及疗程中每个月收集一次24h 全尿样,记录总尿量,测定尿蛋白和肌酐。同时采集全血、血浆、血清样本,测定血红蛋白 A_(1C)、纤维蛋白原和肌酐。结果 1985, Solerte et al. Reported that diabetic patients treated with pentoxifylline 4 months later, proteinuria and fibrinogen decreased 46% and 18%, respectively, presumably a decrease in fibrinogen, coupled with the decrease in plasma viscosity leads to proteinuria Decrease. The author of this study gave four normotensive diabetic patients with proteinuria pentoxifylline 400 mg x 3 / d for 4 months. All patients were routinely confirmed by evidence of proteinuria. In addition to the addition of pentoxifylline, from 2 months before treatment to 4 months after the end of treatment, the patient’s medication is the same as before. Pentoxifylline treatment before treatment and monthly collection of 24 hours a total urine sample, record the total urine output, urine protein and creatinine. At the same time, whole blood, plasma and serum samples were collected and hemoglobin A_ (1C), fibrinogen and creatinine were measured. result