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为研究口服药物控释微球的制备及其体外释药性质 ,以格列吡嗪为模型药物 ,采用喷雾干燥法制备具有恒速释药性质的微球。通过考察微球的收率、包封率以及体外释放特性 ,研究了载体材料、材料与药物比例以及药物释放环境对格列吡嗪控释微球释药性质的影响。结果表明 ,采用醋酸纤维素为载体材料 ,选用合适的配方 ,可制得具有零级释药动力学的格列吡嗪控释微球制剂 ,并且该制剂可以根据需要的条件在 12 h或 2 4 h内释放完毕。不同条件下微球的药物释放曲线线性拟合的相关系数在 0 .981～ 0 .999之间
To study the preparation of oral controlled-release microspheres and its in vitro release properties, glipizide was used as a model drug to prepare microspheres with constant drug releasing rate by spray drying. By investigating the yield, entrapment efficiency and in vitro release characteristics of microspheres, the effects of carrier material, material to drug ratio and drug release environment on the drug release properties of glipizide controlled release microspheres were investigated. The results showed that glibenclamide controlled release microspheres with zero order release kinetics could be obtained by using cellulose acetate as the carrier material and selecting the appropriate formula, and the preparation could be prepared according to the required conditions at 12 h or 2 Release within 4 h is completed. Under different conditions, the correlation coefficient of linear fitting of drug release curve of microspheres was between 0.981 ~ 0.999