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目的:观察酪酸梭菌活菌散联合锌剂治疗婴幼儿肺炎继发性腹泻的疗效。方法:婴幼儿肺炎继发性腹泻患儿240例,随机分为治疗组和对照组各120例。两组在积极治疗原发病基础上给予纠正脱水、电解质紊乱及酸碱平衡等对症支持治疗;对照组给予酪酸梭菌活菌散口服,1岁以内每次0.25 g,1岁以上每次0.5 g,3次/天,疗程7～10 d;治疗组口服酪酸梭菌活菌散联合葡萄糖酸锌,以锌计算,1岁以内10 mg/d,1岁以上20 mg/d,疗程均7～10 d。比较两组脱水纠正时间、恢复进食时间、住院时间及治疗后的有效率。结果:治疗组总有效率96.7%,对照组总有效率75.8%,两组比较差异有统计学意义(P<0.01)。治疗组平均住院时间为(5.6±1.8)d,对照组平均住院时间为(8.7±2.2)d,两组比较差异有统计学意义(P<0.01)。结论:酪酸梭菌活菌散联合锌剂治疗婴幼儿肺炎继发性腹泻安全有效,能缩短治疗时间,值得临床推广。
Objective: To observe the curative effect of Clostridium butyricum combined with Zinc powder in the treatment of secondary diarrhea of infantile pneumonia. Methods: A total of 240 infants with pneumonia secondary diarrhea were randomly divided into treatment group (120 cases) and control group (120 cases). The two groups were given positive symptomatic supportive treatment of dehydration, electrolyte imbalance and acid-base balance on the basis of active treatment of the primary disease; the control group was given Clostridium butyricum oral bacteria, 0.25 g per one year old and 0.5 per one year old g, 3 times / day for 7 ~ 10 days. The treatment group oral Clostridium butyricum viable combined with zinc gluconate, calculated as zinc, 10 mg / d within 1 year, 20 mg / d above 1 year, ~ 10 d. The dehydration correction time, recovery time, hospitalization time and the effective rate after treatment were compared between the two groups. Results: The total effective rate was 96.7% in the treatment group and 75.8% in the control group. There was significant difference between the two groups (P <0.01). The average length of stay in the treatment group was (5.6 ± 1.8) days, and the average length of stay in the control group was (8.7 ± 2.2) days. There was significant difference between the two groups (P <0.01). Conclusion: Clostridium butyricum combined with zinc agent is safe and effective in the treatment of secondary diarrhea of pneumonia in infants and young children. It can shorten the treatment time and is worthy of clinical promotion.