目的　观察老年性骨质疏松患者转化生长因子 β1 (TGF β1 )、胰岛素样生长因子 - 1(IGF 1) ,表皮生长因子 (EGF)血清水平以及与骨质疏松的相关性。方法　采用双能X线骨密度仪测量了 86例在本院老年病门诊和住院的老年人腰椎正位以及股骨颈、ward三角区、大粗隆部位的骨密度 (BMD) ,受试者均为老年男性 ,平均年龄为 6 9 97± 5 73岁 ,按照WHO推荐的诊断标准 ,参考中国人骨质疏松症建议诊断标准 (第二稿 ) ,将其分为非骨质疏松组 (NOP)、腰椎骨质疏松组 (OP1 )和股骨上段骨质疏松组 (OP2 ) ,测定所有受试者血清TGF β1 ,IGF 1,EGF水平。结果　腰椎骨质疏松组和股骨上段骨质疏松组血清IGF 1浓度值均低于非骨质疏松组 ((P <0 0 1) )。腰椎骨质疏松组血清TGF β1 浓度值与非骨质疏松组无明显差异 ((P >0 0 5 ) ) ,股骨上段骨质疏松组血清TGF β1 浓度值低于非骨质疏松组 (0 0 1

0 5 )。腰椎骨密度值与血清IGF 1值呈正相关 (相关系数分别为 :0 2 12、0 32 5、0 2 2 8) ,腰椎骨密度值与血清TGF β1 值呈显著正相关 (相关系数分别为 :0 373、0 32 8、0 341、P <0 0 5 )。股骨颈、Ward三角、大粗隆的骨密度值与IGF 1和TGF β1 无显著相关 Objective To observe the serum levels of transforming growth factor β1 (TGF β1), insulin-like growth factor-1 (IGF 1) and epidermal growth factor (EGF) in senile osteoporosis patients and its relationship with osteoporosis. Methods Bone mineral density (BMD) in the anteroposterior lumbar vertebra and the femoral neck, ward trigone area and the greater trochanter were measured in 86 elderly patients in our hospital from outpatients and inpatients using dual energy X-ray absorptiometry. All subjects The mean age was 697 ± 573 years old. According to the diagnostic criteria recommended by the WHO, refer to the Chinese Second National People’s Osteoporosis Diagnostic Criteria (second draft), which were divided into non-osteoporosis group (NOP) , Osteoporosis group (OP1) and osteoporosis group (OP2) in the upper femur. Serum levels of TGFβ1, IGF1 and EGF were measured in all subjects. Results Serum concentrations of IGF1 in lumbar osteoporosis group and upper femoral osteoporosis group were significantly lower than those in non-osteoporosis group (P <0.01). The serum concentration of TGFβ1 in lumbar osteoporosis group had no significant difference with that in non-osteoporosis group (P> 0.05). The serum TGFβ1 level in osteoporosis group was lower than that in non-osteoporosis group 1

0.05). The BMD of lumbar vertebrae was positively correlated with the level of serum IGF1 (the correlation coefficients were 0 2 12,0 32 5,0 2 2 8 respectively). The BMD of lumbar spine was positively correlated with serum TGF β1 (the correlation coefficients were: 0 373,0 32 8,0 341, P <0 0 5). The femoral neck, Ward triangle, greater trochanter BMD values ​​were not significantly correlated with IGF 1 and TGF β 1