4-(3-氧代-4-吗啉基)苯胺与氯甲酸苄酯发生取代反应制得N-[4-(3-氧代-4-吗啉基)苯基]氨基甲酸苄酯,后者与(S)-N-[(2-乙酰氧基-3-氯)丙基]乙酰胺经缩合制得(S)-3-[4-(3-氧代-4-吗啉基)苯基]-5-乙酰胺甲基-1,3-噁唑烷-2-酮,再经酸性水解即可制得合成利伐沙班的重要中间体(S)-3-[4-(3-氧代-4-吗啉基)苯基]-5-氨甲基-1,3-噁唑烷-2-酮,总收率约35%。 The benzyl N- [4- (3-oxo-4-morpholinyl) phenyl] carbamate was substituted by 4- (3- The latter is condensed with (S) -N - [(2-acetoxy-3-chloropropyl) acetamide to give (S) -3- [4- ) Phenyl] -5-acetamidomethyl-1,3-oxazolidin-2-one, and then acid hydrolysis can be obtained as an important intermediate for the synthesis of rivaroxaban (S) -3- [4- (3-oxo-4-morpholinyl) phenyl] -5-aminomethyl-1,3-oxazolidin-2-one in about 35% overall yield.