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目的:研究蛋白酪氨酸磷酸酶SHP-2(Src homology 2 domain-containing phosphatase)在喉癌(Laryngeal squamous carcinoma,LSC)组织中的表达水平,初步探讨SHP-2与LSC发生发展的关系。方法:入选17例LSC患者,免疫组化染色检测SHP-2表达,显微镜下观察阳性率,取4例喉癌患者的正常粘膜组织为对照组。结果:SHP-2在喉癌组织中的表达与正常粘膜组织中的表达差异有显著性意义;喉癌组织中SHP-2的表达与淋巴结转移存在正相关。结论:SHP-2在LSC组织中的表达显著增高,可能与LSC发生发展的机制有关;SHP-2在不同级别LSC组织中的表达无明显差异,与临床分期无关,提示SHP-2对LSC的分化程度可能不起重要作用。
OBJECTIVE: To investigate the expression of SHC-2 (SHP-2) in laryngeal squamous carcinoma (LSC) and to investigate the relationship between SHP-2 and the occurrence and development of LSC. Methods: 17 cases of LSC were enrolled. The expression of SHP-2 was detected by immunohistochemical staining. The positive rate was observed under the microscope. The normal mucosa of 4 cases of laryngeal carcinoma were taken as the control group. Results: The expression of SHP-2 in laryngeal carcinoma tissues was significantly different from that in normal mucosa tissues. There was a positive correlation between the expression of SHP-2 and lymph node metastasis in laryngeal carcinoma. Conclusions: The expression of SHP-2 in LSC was significantly increased, which may be related to the development of LSC. The expression of SHP-2 in different grades of LSC showed no significant difference, which was not related to clinical stage, suggesting that SHP- The degree of differentiation may not play an important role.