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目的 探讨单纯性肥胖青少年体脂分布与血压及胰岛素抵抗之间的关系。方法 测定了 2 7例单纯性肥胖青少年及 10例非肥胖健康人空腹及口服 75g糖后 1h、2h的血糖及胰岛素浓度 ,计算胰岛素敏感指数 (ISI,RISI) ,比较各指标间的相关性。结果 肥胖患者基础及服 75g糖后 1h、2h胰岛素值均高于对照组 (P <0 .0 0 1) ,胰岛素敏感指数 (ISI,RISI)低于对照组 ,中心型肥胖患者血压高于对照组 (P <0 .0 0 1) ,中心型肥胖组胰岛素敏感指数ISI低于周围型肥胖组。结论 肥胖青少年体内存在着高胰岛素血症 ,胰岛素抵抗及血压偏高的倾向 ,此种情况以中心型肥胖者为著。ISI能更好地反应肥胖患者胰岛素的敏感性
Objective To investigate the relationship between body fat distribution and blood pressure and insulin resistance in simple obese adolescents. Methods Serum glucose and insulin concentrations were measured at 1 h and 2 h after fasting and oral administration of 75 g of sugar in 27 simple obese adolescents and 10 non-obese healthy adults. ISI and RISI were calculated and their correlations were compared. Results The insulin levels at 1 h and 2 h after oral administration of 75 g glucose in obese patients were significantly higher than those in control group (P <0.01). The insulin sensitivity index (ISI, RISI) was lower in obese patients than in control group. Group (P <0.001). The ISI of central obesity group was lower than that of peripheral obesity group. Conclusion There is a tendency of hyperinsulinemia, insulin resistance and high blood pressure in obese adolescents. This situation is mainly caused by central obesity. ISI can better reflect the insulin sensitivity of obese patients