论文部分内容阅读
目的:观察双歧杆菌三联活菌联合谷氨酰胺对合并胃肠功能障碍的重症肺炎患儿的疗效。方法:2013年1月-2015年12月收治本院儿科重症监护病房治疗的80例合并胃肠功能障碍的重症肺炎患儿,随机分为治疗组和对照组,每组各40例患儿。对照组采用常规综合治疗,治疗组在对照组基础上加用双歧杆菌三联活菌联合谷氨酰胺。观察两组患儿治疗前后血浆D-乳酸和二胺氧化酶含量、多脏器功能障碍及其它并发症发生率、PiO_2/FiO_2改善情况,以评价联合应用双歧杆菌三联活菌与谷氨酰胺对重症肺炎患儿的疗效。结果:治疗组38例,对照组36例完成研究。两组患儿血浆D-乳酸及DAO水平随治疗时间延长逐渐降低,相同时间点治疗组患儿D-乳酸水平显著低于对照组(P<0.01)。治疗组患儿多器官功能障碍综合征(MODS)发生率为2.63%,显著低于对照组的19.44%(P<0.05);治疗组患儿总体并发症发生率为7.89%,显著低于对照组的80.55%(P<0.01);治疗组随时间延长PiO_2/FiO_2逐渐增高,不同时间点均高于对照组(P<0.01)。结论:联合应用双歧杆菌三联活菌与谷氨酰胺可以显著改善患儿胃肠功能,降低MODS和其它并发症发生率,改善氧合指数,对重症肺炎起到治疗作用。
Objective: To observe the effect of live bifidobacterium combined with glutamine on severe pneumonia in children with gastrointestinal dysfunction. Methods: From January 2013 to December 2015, 80 children with severe pneumonia with gastrointestinal dysfunction admitted to our pediatric intensive care unit were randomly divided into treatment group and control group with 40 cases in each group. The control group with conventional comprehensive treatment, the treatment group on the basis of the control group plus Bifidobacterium triple viable bacteria combined with glutamine. The levels of plasma D-lactate and diamine oxidase, the incidence of multiple organ dysfunction and other complications, and the improvement of PiO 2 / FiO 2 were observed before and after treatment in both groups to evaluate the efficacy of combination of Bifidobacterium triple viable with glutamine The effect of severe pneumonia in children. Results: The treatment group 38 cases, the control group of 36 patients completed the study. The levels of D-lactate and DAO in both groups decreased gradually with the prolongation of treatment time. The levels of D-lactate in the treatment group were significantly lower than those in the control group at the same time point (P <0.01). The incidence of multiple organ dysfunction syndrome (MODS) in treatment group was 2.63%, which was significantly lower than that in control group (19.44%, P <0.05). The overall complication rate in treatment group was 7.89%, which was significantly lower than that in control group (P <0.01). PiO 2 / FiO 2 in treatment group increased gradually with time, and were higher than those in control group at different time points (P <0.01). Conclusion: Combined use of live bifidobacterium and glutamine can significantly improve children ’s gastrointestinal function, reduce the incidence of MODS and other complications, improve oxygenation index and play a therapeutic role in severe pneumonia.