Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：ZYONGF

【摘要】

：

Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method.The results showed that some

【作者】

：

Liang You Wan Nian Zhang Zhen

【机构】

：

School of Pharmacy

【出处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

Homocamptotbecin Amino acids ester Antitumor activity Synthesis

【基金项目】

：

上海市重点学科建设项目;Shanghai Major Program Science and Technology Foundation;国家自然科学基金

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Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method.The results showed that some of the compound had higher antitumor activity than iritecan.

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Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

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