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目的探讨氟马西尼治疗急性重度苯二氮艹卓 类药物 (BZDs)中毒的临床价值。方法将急性重度BZDs中毒患者 4 0例随机分为两组 ,氟马西尼组 2 0例 ,常规治疗组 2 0例。疗效评判采用Glasgow～Pittsburgh昏迷深度评定方法和观察者对患者机敏力 /镇静程度评判量表 (OAA/S)指标。结果治疗组经氟马西尼治疗后昏迷深度显著改善 (除 5分钟P <0 0 5外 ,其余P <0 0 1)。以OAA/S指标比较两组疗效差异亦具有显著意义 (P <0 0 1)。结论氟马西尼可作为治疗急性重度BZDs中毒的特效解毒药 ,且疗效稳定 ,无明显毒副反应。
Objective To investigate the clinical value of flumazenil in the treatment of acute severe benzodiazepines (BZDs) poisoning. Methods Forty patients with acute severe BZDs poisoning were randomly divided into two groups: 20 cases in flumazenil group and 20 cases in routine treatment group. Efficacy evaluation using Glasgow ~ Pittsburgh coma depth assessment methods and observers of patients with sensitivity / sedation rating scale (OAA / S) indicators. Results After treatment with flumazenil, the coma depth was significantly improved in the treatment group (P <0 0 5 except for 5 minutes P <0 05). To OAA / S indicators of differences between the two groups also have significant differences (P <0.01). Conclusion Flumazenil can be used as a special antidote for the treatment of acute severe BZDs poisoning, and its efficacy is stable with no obvious side effects.