1临床资料患者男,14岁。齿龈发黑8年余,渐扩及全身。8年前患者口腔内齿龈无诱因明显变黑,逐渐累及唇和唇周皮肤、耳面部、四肢及躯干部位,近3个月皮肤颜色较前加深明显。发病以来时感全身乏力,并易患感冒发热。父母非近亲结婚,家族及生活环境中无类似病史,成绩一般,不喜活动。 1 clinical data patient male, 14 years old. Gingival black more than 8 years, gradually expanding and body. Eight years ago, the gums in the oral cavity of patients were obviously darken, gradually involving the labial, labial and facial parts, and the limbs and trunk areas. The skin color of the patients in the past three months was obviously deepened. Since the onset of symptoms of generalized fatigue, and susceptible to cold and fever. Parents of non-relatives married, family and living environment without a similar history, the results in general, do not like activities.