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应用增殖细胞核抗原（ｐｒｏｌｉｆｅｒａｔｉｎｇｃｅｌｎｕｃｌｅａｒａｎｔｉｇｅｎ，ＰＣＮＡ）单克隆抗体ＰＣ１０，以Ｓ－Ｐ免疫组织化学染色方法观察分析ＰＣＮＡ在涎腺混合瘤、混合瘤细胞生长活跃型、恶性混合瘤、粘液表皮样癌中的表达分布情况。评价不同组织类型的涎腺肿瘤的增殖潜能及同一肿瘤组织中不同细胞成分的增殖活性。结果表明：恶性混合瘤有较高的ＰＣＮＡ增殖指数，与混合瘤细胞生长活跃型及混合瘤相比均有极显著性差异（Ｐ＜０．０１）；低分化粘液表皮样癌与高分化型相比有极显著性差异（Ｐ＜０．０１）。结论：ＰＣＮＡ是肿瘤细胞增殖的有效标记物；可作为恶性混合瘤的诊断指标；ＰＣＮＡ增殖指数可作为粘液表皮样癌组织学分级的重要参数。
PCNA monoclonal antibody PC10 was used to observe the expression of PCNA in salivary gland mixed tumor, mixed tumor cell growth active, malignant mixed tumor and mucoepidermoid carcinoma by S-P immunohistochemical staining Distribution. To evaluate the proliferation potential of salivary gland tumors of different tissue types and the proliferative activity of different cell components in the same tumor tissue. The results showed that malignant mixed tumor had higher proliferative index of PCNA, which was significantly different from mixed tumor growth and mixed tumor (P <0.01); poorly differentiated mucoepidermoid carcinoma with highly differentiated Compared with a very significant difference (P <0.01). Conclusion: PCNA is an effective marker of tumor cell proliferation; it can be used as a diagnostic indicator of malignant mixed tumor; PCNA proliferation index can be used as an important parameter of histological grading of mucoepidermoid carcinoma.