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目的探讨术前服用米非司酮对依沙吖啶中期妊娠引产的临床效果。方法 200名孕12～28周妇女,随机分为观察组和对照组,每组100名。观察组经腹壁向羊膜腔内注入依沙吖啶100mg,随即顿服米非司酮150mg;对照组不加用米非司酮,比较两组的引产情况及清宫率。结果观察组引产开始至胎儿娩出时间及总产程均短于对照组(P<0.01),清宫率小于对照组(P<0.05)。引产成功率、产后出血量无显著性差异。结论米非司酮联合依沙吖啶用于中期妊娠引产,可有效促进宫颈成熟,缩短引产和总产程时间,降低宫缩痛程度,有效减少胎盘、蜕膜残留,降低清宫率,是一种较好的中期妊娠引产方法。
Objective To investigate the clinical effect of mifepristone on induction of labor with midazolam in the second trimester of pregnancy. Methods 200 pregnant women aged 12-28 weeks were randomly divided into observation group and control group with 100 in each group. In the observation group, 100 mg of ethacridine was infused into the amniotic cavity via the abdominal wall immediately after taking 150 mg of mifepristone. Mifepristone was not given in the control group. Rates of induced labor and rates of cesarean section were compared between the two groups. Results The observation group was shorter than the control group (P <0.01), and the rate of curettage was lower than that of the control group (P <0.05). Successful induction of labor, postpartum hemorrhage no significant difference. Conclusion Mifepristone combined with ethacridine for induction of labor in the second trimester of pregnancy can effectively promote cervical maturation, shorten the time of induction and total labor, reduce the degree of uterine contraction, reduce placental and decidual remnants, and reduce the rate of uterine bleeding Better midwifery induction of labor.