组织胺H_2受体拮抗剂甲腈咪胍是治疗消化性溃疡的有效药物,可用于胃溃疡和糜烂性胃炎,也可用于治疗和预防应激性溃疡。开始时认为它的副反应很少,但随着使用的增加,发现可引起精神错乱、骨髓抑制和精子数减少等反应。甲腈咪胍尚可使以下药物的代谢受到抑制:如安替匹林、苄丙酮羟香豆素、安定、利眠宁、心得安、茶碱、卡马西平和苯妥英钠等。这些相互作用颇为重要,有时甚至可危及生命。作者报告一例因甲腈咪胍干扰丙咪嗪和去甲丙咪嗪代谢,导致其血浓度增加者。病例:女性,32岁,因三次抑郁发作而住院。符合DSM-Ⅲ重症抑郁的标准,因左膝关节痛、腹痛服用甲腈咪胍300mg,每日 Histamine H 2 receptor antagonist Cimetidine is an effective drug for the treatment of peptic ulcer, which can be used for gastric ulcer and erosive gastritis, and also for the treatment and prevention of stress ulcer. Initially it was thought that there were few side effects, but as the use increased, it was found to cause confusion, myelosuppression and sperm count reduction. Cimetidine can also inhibit the metabolism of such drugs as anti-aspirin, hydroxybenzoic acid coumarin, diazepam, chlordiazepoxide, propranolol, theophylline, carbamazepine and phenytoin and so on. These interactions are important and sometimes life-threatening. The authors report a case of cetuximab interfering with imipramine and desipramine metabolism, resulting in increased blood concentrations. Case: Female, 32 years old, hospitalized for three episodes of depression. In line with the DSM-Ⅲ criteria for major depression, because of left knee pain, abdominal pain taking cilium 300mg, daily